Zinc PCA

Mineral Sebum Regulator

Also known as: Zinc Pidolate, Zinc L-Pyrrolidone Carboxylate

Description

Zinc PCA is the zinc salt of pyrrolidone carboxylic acid (PCA), a natural component of the skin's Natural Moisturizing Factor (NMF). It combines the sebum-regulating properties of zinc with the humectant properties of PCA, making it particularly suited for oily and acne-prone skin types.

Mechanism of Action

The zinc ion inhibits 5α-reductase, reducing the conversion of testosterone to dihydrotestosterone (DHT) and thereby decreasing sebum production. Zinc also has intrinsic antimicrobial properties against Propionibacterium acnes by disrupting its lipase activity. The PCA moiety acts as a humectant, attracting and retaining moisture in the stratum corneum without contributing oiliness. Additionally, zinc supports wound healing through its role as a cofactor in metalloproteinases involved in tissue repair.

Indications

  • Oily skin
  • Acne-prone skin
  • Seborrheic dermatitis
  • Enlarged pores
  • Combination skin hydration

Available Concentrations

0.5%1%2%4%

Side Effects

  • Mild dryness (at high concentrations)
  • Skin irritation (rare)

Contraindications

  • Known hypersensitivity to zinc compounds

Pregnancy Category

Not classified (generally considered safe)

Found In

Cosmetics containing Zinc PCA

Minimalist 10% Niacinamide Face SerumMinimalist

Related Conditions

Acne Vulgaris Sebum control and mild antimicrobial Seborrheic Dermatitis Antimicrobial and sebum-regulating