Panthenol
Also known as: Pro-Vitamin B5, Dexpanthenol, D-Panthenol, Provitamin B5
Description
Panthenol (D-panthenol or dexpanthenol) is the alcohol analogue of pantothenic acid (vitamin B5). Upon topical application, it is converted to pantothenic acid, which is a component of coenzyme A. It is widely used in skincare and wound care for its moisturizing, anti-inflammatory, and barrier-repair properties.
Mechanism of Action
After penetrating the epidermis, panthenol is enzymatically oxidized to pantothenic acid, which is incorporated into coenzyme A (CoA). CoA is essential for lipid synthesis and energy metabolism in keratinocytes, supporting barrier repair and cell proliferation. Panthenol also acts as a humectant, attracting and binding water in the stratum corneum. It stimulates fibroblast proliferation and accelerates re-epithelialization in wound healing. Anti-inflammatory effects are mediated through modulation of IL-6 and IL-8 expression.
Indications
- Dry and dehydrated skin
- Wound healing
- Skin barrier repair
- Diaper rash
- Minor burns and irritation
- Post-procedural care
- Eczema (adjunct)
Available Concentrations
Side Effects
- Very rarely causes irritation
- Contact allergy (extremely rare)
Contraindications
- Known hypersensitivity to panthenol
Pregnancy Category
Not classified (generally considered safe)