Niacinamide
Vitamin B3 Derivative
Also known as: Nicotinamide, Vitamin B3 amide
Description
Niacinamide is the physiologically active amide form of vitamin B3. It is a versatile, well-tolerated compound with anti-inflammatory, sebum-regulating, and barrier-strengthening properties.
Mechanism of Action
Inhibits sebocyte lipogenesis and reduces sebum production. Enhances synthesis of ceramides and other intercellular lipids, strengthening the epidermal barrier. Inhibits melanosome transfer to keratinocytes. Suppresses NF-κB pathway activation.
Indications
- Acne vulgaris
- Rosacea
- Melasma
- Atopic dermatitis
- Photoaging
- Hyperpigmentation
Available Concentrations
Side Effects
- Mild flushing (rare at topical doses)
- Mild irritation in sensitive individuals
Contraindications
- Known hypersensitivity
Pregnancy Category
A
Found In
Cosmetics containing Niacinamide
Cetaphil Gentle Skin CleanserCetaphil (Galderma)Cipla Excela MoisturiserCipla (Rivela Dermascience)Deconstruct Pore Control Serum — 2% Salicylic Acid + 3% NiacinamideDeconstructDot & Key 10% Glycolic Acid Glow SerumDot & KeyMinimalist 10% Niacinamide Face SerumMinimalistRe'equil Ceramide & Hyaluronic Acid MoisturiserRe'equil
Related Conditions
Acne Vulgaris
Sebum regulation and anti-inflammatory
Rosacea
Barrier repair and anti-inflammatory adjunct
Melasma
Inhibits melanosome transfer to keratinocytes
Atopic Dermatitis
Enhances ceramide synthesis and reduces inflammation
Photoaging
Improves fine lines, pigmentation, and barrier function
Psoriasis
Anti-inflammatory and barrier-repair adjunct
Seborrheic Dermatitis
Anti-inflammatory and barrier support
Xerosis
Stimulates ceramide synthesis and improves barrier