Hydrocortisone

Corticosteroid (Low Potency)

Also known as: Cortisol, Hydrocortisone acetate

Description

Hydrocortisone is a low-potency topical corticosteroid identical to endogenous cortisol. It is the mildest prescription-strength steroid and is available over-the-counter in many countries.

Mechanism of Action

Binds to intracellular glucocorticoid receptors, translocating to the nucleus and modulating gene expression. Suppresses phospholipase A2, reducing prostaglandin and leukotriene synthesis. Inhibits inflammatory cell migration and cytokine release.

Indications

  • Eczema (mild)
  • Contact dermatitis
  • Insect bite reactions
  • Seborrheic dermatitis
  • Mild psoriasis
  • Pruritus

Available Concentrations

0.5%1%2.5%

Side Effects

  • Skin atrophy (prolonged use)
  • Telangiectasia
  • Striae
  • Perioral dermatitis
  • Acneiform eruptions
  • Hypopigmentation

Contraindications

  • Untreated bacterial or fungal infections
  • Rosacea
  • Perioral dermatitis
  • Ulcerated skin

Pregnancy Category

C

Found In

Drugs containing Hydrocortisone

CortaidHydrocortisone Cream

Related Conditions

Atopic Dermatitis Low-potency corticosteroid for flare management Psoriasis Mild corticosteroid for facial/flexural psoriasis Seborrheic Dermatitis Mild steroid for facial involvement Contact Dermatitis First-line low-potency topical steroid for mild cases