Coenzyme Q10
Also known as: Ubiquinone, CoQ10, Ubidecarenone
Description
Coenzyme Q10 (ubiquinone) is a naturally occurring lipid-soluble benzoquinone that is present in virtually all human cells. It plays a dual role as an essential component of the mitochondrial electron transport chain and as a potent lipophilic antioxidant. Skin levels of CoQ10 decline significantly with age and UV exposure, making it a popular anti-aging ingredient.
Mechanism of Action
In its reduced form (ubiquinol), CoQ10 donates electrons to neutralize free radicals, protecting cell membranes and mitochondrial DNA from oxidative damage. It inhibits lipid peroxidation in the stratum corneum and dermis. CoQ10 also supports cellular energy production by shuttling electrons between Complex I/II and Complex III of the mitochondrial electron transport chain, fueling keratinocyte and fibroblast metabolism. It has been shown to reduce UV-induced MMP-1 expression, protecting collagen from photodegradation, and to reduce depth of wrinkles with regular use.
Indications
- Photoaging
- Fine lines and wrinkles
- Oxidative stress protection
- Energizing dull skin
- Post-sun exposure care
Available Concentrations
Side Effects
- Very well tolerated
- Rare mild irritation
- Yellow-orange tint at high concentrations
Contraindications
- Known hypersensitivity (extremely rare)
Pregnancy Category
Not classified (topical use generally considered safe)