Clindamycin
Lincosamide Antibiotic
Also known as: Clindamycin phosphate
Description
Clindamycin is a lincosamide antibiotic effective against gram-positive bacteria, particularly Cutibacterium acnes. It is commonly used topically for acne and is frequently combined with benzoyl peroxide to reduce antibiotic resistance.
Mechanism of Action
Binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. Suppresses Cutibacterium acnes proliferation and reduces free fatty acid levels on the skin surface. Also exhibits anti-inflammatory activity.
Indications
- Acne vulgaris (inflammatory)
- Bacterial skin infections
- Rosacea (adjunctive)
Available Concentrations
Side Effects
- Dryness
- Skin irritation
- Contact dermatitis
- Pseudomembranous colitis (rare, topical)
Contraindications
- History of pseudomembranous colitis
- Hypersensitivity to clindamycin or lincomycin
- History of antibiotic-associated colitis
Pregnancy Category
B