Ceramides
Also known as: Ceramide 3, Sphingolipids
Description
Ceramides are a family of waxy lipid molecules that make up approximately 50% of the lipids in the stratum corneum. They play a critical role in maintaining the skin's barrier function and preventing transepidermal water loss (TEWL). In skincare, they are typically used alongside cholesterol and fatty acids to mimic the natural lipid matrix of healthy skin.
Mechanism of Action
Ceramides integrate into the lamellar lipid bilayers of the stratum corneum, restoring the intercellular lipid matrix. They form a water-impermeable barrier that reduces TEWL and protects against external irritants and pathogens. When used with cholesterol and free fatty acids in a physiological ratio, they mimic the skin's natural lipid organization, accelerating barrier repair.
Indications
- Impaired skin barrier
- Eczema / atopic dermatitis
- Dry skin / xerosis
- Post-procedural care
- Sensitive or irritated skin
- Adjunct to retinoid therapy
Available Concentrations
Side Effects
- Extremely rare irritation
- Generally considered non-irritating
Contraindications
- Known hypersensitivity (extremely rare)
Pregnancy Category
Not classified (generally considered safe)