Centella Asiatica Extract
Also known as: Cica, Gotu Kola, Madecassoside, Asiaticoside
Description
Centella asiatica is a herbaceous plant used for centuries in Ayurvedic and traditional medicine. Its dermatological activity is attributed to four key triterpenoid saponins: madecassoside, asiaticoside, asiatic acid, and madecassic acid (collectively known as centelloids). These compounds stimulate type I and III collagen synthesis, promote fibroblast proliferation, inhibit inflammatory cytokines, and accelerate wound healing. Centella extract is widely used in Korean skincare ('Cica' products) for calming sensitive, irritated, and acne-prone skin.
Mechanism of Action
Asiaticoside and madecassoside stimulate collagen synthesis by activating the TGF-β/Smad signaling pathway in dermal fibroblasts and upregulating type I procollagen gene expression. Asiatic acid increases antioxidant enzyme activity (SOD, catalase, glutathione peroxidase) and inhibits NF-κB-mediated pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6). Madecassoside promotes angiogenesis and re-epithelialization in wound models. Together, centelloids modulate both the inflammatory and proliferative phases of tissue repair.
Indications
- Wound healing and scar management
- Acne and post-acne erythema
- Sensitive or irritated skin
- Rosacea-prone skin
- Photoaging / fine lines
- Atopic dermatitis adjunct
- Post-procedural recovery
- Stretch marks (striae)
Available Concentrations
Side Effects
- Allergic contact dermatitis (uncommon; sensitization to triterpenoid fraction)
- Mild irritation in rare cases
Contraindications
- Known hypersensitivity to Centella asiatica or its triterpenoids
- History of allergic contact dermatitis to Centella-containing products
Pregnancy Category
Not classified (insufficient data; generally considered safe for topical use at cosmetic concentrations)