Bakuchiol
Also known as: Babchi Extract
Description
Bakuchiol is a meroterpene (terpenoid phenol) isolated from the seeds and leaves of Psoralea corylifolia (Babchi). It is functionally similar to retinol, modulating retinol-like gene expression involved in collagen synthesis, cell turnover, and melanogenesis, but does not bind retinoid receptors (RARs/RXRs) and is structurally unrelated to retinoids. Clinical trials have demonstrated comparable anti-aging and anti-pigmentation efficacy to 0.5% retinol, with significantly fewer side effects such as dryness, scaling, and photosensitivity.
Mechanism of Action
Bakuchiol modulates retinol-like gene expression through a retinoid receptor-independent mechanism, upregulating types I, III, and IV collagen gene expression and stimulating collagen synthesis in dermal fibroblasts. It inhibits melanogenesis by suppressing tyrosinase activity and reduces MMP-1 expression, thereby decreasing collagen degradation. Bakuchiol also exhibits antioxidant activity by scavenging free radicals and anti-inflammatory properties by inhibiting NF-κB and COX-2 pathways. Unlike retinoids, it does not increase photosensitivity.
Indications
- Photoaging / fine lines and wrinkles
- Hyperpigmentation
- Acne vulgaris
- Uneven skin tone
- Retinoid-intolerant patients
- Pregnancy-safe alternative to retinoids
Available Concentrations
Side Effects
- Mild irritation (less common than retinol)
- Rare allergic contact dermatitis
- Generally well tolerated
Contraindications
- Known hypersensitivity to bakuchiol or Psoralea corylifolia
Pregnancy Category
Not formally classified (considered safer alternative to retinoids during pregnancy; no teratogenic data reported)