Alpha Arbutin
Skin Brightening Agent
Also known as: α-Arbutin, 4-Hydroxyphenyl α-D-glucopyranoside
Description
Alpha arbutin is a biosynthetic glycosylated hydroquinone derivative that inhibits melanin production. It is more stable and considered safer than hydroquinone, making it a popular depigmenting agent in Indian and Asian skincare. It works by reversibly inhibiting tyrosinase without cytotoxic effects on melanocytes.
Mechanism of Action
Reversibly inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis. Unlike hydroquinone, it does not cause melanocyte death. Slowly releases hydroquinone in a controlled manner, reducing the risk of irritation and ochronosis.
Indications
- Melasma
- Post-inflammatory hyperpigmentation
- Sun spots
- Uneven skin tone
- Dark spots
Available Concentrations
Side Effects
- Mild irritation (rare)
- Contact dermatitis (very rare)
Contraindications
- Known hypersensitivity to arbutin or hydroquinone
Pregnancy Category
Not classified (consult dermatologist)