Allantoin
Also known as: 5-Ureidohydantoin, Glyoxyldiureide
Description
Allantoin is a naturally occurring nitrogenous compound found in botanical extracts (particularly comfrey), animal secretions (snail mucin), and produced synthetically for cosmetic use. It is classified as a skin protectant by the FDA and is widely used for its soothing, anti-irritant, and cell-proliferating properties.
Mechanism of Action
Allantoin promotes cell proliferation by stimulating fibroblast synthesis of extracellular matrix components. It increases the water content of the stratum corneum by enhancing desquamation of dead surface cells, which in turn smooths the skin's texture. It provides anti-irritant effects by forming complexes with irritant substances and sensory irritants. Its keratolytic action at higher concentrations aids in gentle exfoliation without the irritation associated with AHAs or BHAs.
Indications
- Irritated or sensitized skin
- Wound healing
- Dry and rough skin texture
- Post-procedural care
- Anti-aging (cell renewal support)
- Eczema and psoriasis (adjunct)
Available Concentrations
Side Effects
- Extremely well tolerated
- Very rare contact allergy
Contraindications
- Known hypersensitivity (extremely rare)
Pregnancy Category
Not classified (generally considered safe)