Adapalene

Retinoid (Third Generation)

Also known as: 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid, CD-271

Description

Adapalene is a third-generation synthetic retinoid that selectively binds to RARβ and RARγ receptors. It offers similar efficacy to tretinoin with improved photostability and tolerability.

Mechanism of Action

Selectively binds to nuclear retinoic acid receptors RARβ and RARγ, modulating cellular differentiation and keratinization. Inhibits AP-1 factor and toll-like receptor-mediated inflammatory pathways. More photostable and less irritating than tretinoin.

Indications

  • Acne vulgaris
  • Photoaging (off-label)
  • Keratosis pilaris

Available Concentrations

0.1%0.3%

Side Effects

  • Dryness
  • Erythema
  • Scaling
  • Burning or stinging
  • Photosensitivity (less than tretinoin)

Contraindications

  • Pregnancy
  • Eczematous skin at application site
  • Sunburned skin

Pregnancy Category

C

Found In

Drugs containing Adapalene

DifferinAdapalene GelEpiduoAdapalene and Benzoyl Peroxide Gel

Related Conditions

Acne Vulgaris First-line topical retinoid — comedolytic and anti-inflammatory Keratosis Pilaris Retinoid — reduces follicular plugging